Motif ID: TFAP2{A,C}.p2

Z-value: 2.372


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Cchr20_+_55204307-0.107.2e-01Click!
TFAP2Achr6_-_10412606,
chr6_-_10415438		-0.068.2e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_74707000 6.227 NM_001008528
NM_001008529
NM_198530
 MXRA7


matrix-remodelling associated 7


chr2_-_224903933 5.148 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr11_-_65640199 5.004 NM_016938
 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr1_-_85930610 4.711 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_-_185542807 4.419 NM_001007225
NM_006548
 IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr2_-_20212408 4.297 MATN3
matrilin 3
chr15_-_48937068 4.005 FBN1
fibrillin 1
chr12_-_106641675 3.960 NM_006825
 CKAP4
cytoskeleton-associated protein 4
chr6_+_107811272 3.856 NM_018013
 SOBP
sine oculis binding protein homolog (Drosophila)
chr6_+_151561653 3.801 AKAP12
A kinase (PRKA) anchor protein 12
chr8_-_48650683 3.596 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr19_-_18717467 3.560 CRLF1
cytokine receptor-like factor 1
chr17_-_74707066 3.403 MXRA7
matrix-remodelling associated 7
chr3_-_124774735 3.341 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr19_-_18717631 3.317 NM_004750
 CRLF1
cytokine receptor-like factor 1
chr9_+_137533643 3.296 NM_000093
 COL5A1
collagen, type V, alpha 1
chr3_-_149688638 3.223 NM_002628
NM_053024
 PFN2

profilin 2

chr13_+_98795710 3.137 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr19_-_18717577 3.073 CRLF1
cytokine receptor-like factor 1
chr7_-_45960738 2.966 NM_000598
NM_001013398
 IGFBP3

insulin-like growth factor binding protein 3


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 30 entries
Enrichment   P-value GO Accession GO Term
7.32 2.59e-04 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
6.13 4.14e-02 GO:0030198 extracellular matrix organization
5.23 1.90e-02 GO:0034330 cell junction organization
4.97 1.21e-02 GO:0001525 angiogenesis
4.49 6.05e-03 GO:0048514 blood vessel morphogenesis
4.26 2.22e-03 GO:0001568 blood vessel development
4.24 1.10e-03 GO:0001944 vasculature development
4.00 6.46e-06 GO:0072358 cardiovascular system development
4.00 6.46e-06 GO:0072359 circulatory system development
3.56 1.52e-03 GO:0016477 cell migration
3.31 4.47e-03 GO:0048870 cell motility
3.31 4.47e-03 GO:0051674 localization of cell
3.17 4.28e-02 GO:0009968 negative regulation of signal transduction
3.09 1.19e-02 GO:0048858 cell projection morphogenesis
3.08 1.23e-02 GO:0000904 cell morphogenesis involved in differentiation
3.06 1.37e-02 GO:0032990 cell part morphogenesis
3.04 3.02e-03 GO:0000902 cell morphogenesis
3.02 2.06e-03 GO:0032989 cellular component morphogenesis
2.71 7.82e-04 GO:0040011 locomotion
2.58 1.16e-06 GO:0009653 anatomical structure morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
11.36 2.54e-06 GO:0005604 basement membrane
7.40 4.68e-05 GO:0044420 extracellular matrix part
5.57 5.18e-10 GO:0031012 extracellular matrix
5.38 1.63e-07 GO:0005578 proteinaceous extracellular matrix
4.50 3.20e-02 GO:0005912 adherens junction
4.49 1.43e-02 GO:0070161 anchoring junction
3.05 2.33e-02 GO:0009986 cell surface
2.45 5.80e-04 GO:0044421 extracellular region part
1.81 3.22e-02 GO:0005576 extracellular region
1.69 3.62e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
19.77 7.27e-05 GO:0005520 insulin-like growth factor binding
8.72 1.61e-04 GO:0005201 extracellular matrix structural constituent
6.53 5.94e-04 GO:0019838 growth factor binding
1.33 2.90e-03 GO:0005515 protein binding